Currently browsing: Items authored or edited by Sotiris Missailidis

Khan, Huma; Makwana, Vaidehi; Nascimento dos Santos, Sofia; Bonacossa de Almeida, Carlos Eduardo; Santos-Oliveira, Ralph and Missailidis, Sotiris (2021). Development, Characterization, and In Vivo Evaluation of a Novel Aptamer (Anti-MUC1/Y) for Breast Cancer Therapy. Pharmaceutics, 13(8), article no. e1239.

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Simmons, Suzanne; Velasco, Maria and Missailidis, Sotiris (2012). Development of novel single-stranded nucleic acid aptamers against the pro-Angiogenic and metastatic enzyme heparanase (HPSE1). PLoS ONE

Baouendi, M; Cognet, J. A.; Ferreira, C. S.; Missailidis, S.; Coutant, J.; Piotto, M.; Hantz, E. and Hervé du Penhoat, C. (2012). Solution structure of a truncated anti-MUC1 DNA aptamer determined by mesoscale modeling and NMR. FEBS Journal, 279(3) pp. 479–490.

Gould, A. and Missailidis, S. (2011). Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway. Mini Rev Med Chem., 11(3) pp. 200–213.

Missailidis, Sotiris and Perkins, Alan (2011). Radiolabelled Aptamers for Imaging and Therapy. In: Speer, Tod ed. Targeted Radionuclide Therapy. Lippincott Williams & Wilkins, pp. 59–68.

Da Pieve, Chiara; Williams, Paul; Haddleton, David M.; Palmer, Richard M. J. and Missailidis, Sotiris (2010). Modification of Thiol Functionalized Aptamers by Conjugation of Synthetic Polymers. Bioconjugate Chemistry, 21(1) pp. 169–174.

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Alcaro, Stefano; Artese, Anna; Iley, James N.; Missailidis, Sotiris; Ortuso, Francesco; Parrotta, Lucia; Pasceri, Raffaele; Paduano, Francesco; Sissi, Claudia; Trapasso, Francesco and Vigorita, Maria Gabriella (2010). Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties. ChemMedChem, 5(4) pp. 575–583.

Da Pieve, Chiara; Patel, Pravin and Missailidis, Sotiris (2010). Synthetic route to a benzooxazole derivative with heparanase inhibitory activity. Synthetic Communications, 40(4) pp. 518–522.

Missailidis, S.; Arnold, S.; Simmons, S. C.; Velasco-Garcia, M.; McKenzie, E. A.; Kantiotou, K. and Sotiropoulou, G. (2010). Development of diagnostic and therapeutic aptamers against enzymes crucial for tumour development and metastasis. European Journal of Cancer Supplements, 8(5) pp. 11–12.

Leite Diniz, C.; Da Pieve, C.; Perkins, A.; Haddleton, D. M.; Bernardo-Filho, M.; Santos-Oliveira, R. and Missailidis, S. (2010). Pharmacokinetic and biodistribution studies of anti MUC1 PEGylated aptamers with potential in the targeted radiotherapy of breast cancer. In: EACR21, 26-29 Jun 2010, Oslo, Norway.

Simmons, S.; Brenchley, P. E. C.; McKenzie, E. A.; Velasco, M. and Missailidis, S. (2010). Development of aptamers as tools for the detection and therapy of heparanase in metastatic cancer. In: SET for Britain 2010, 8 Mar 2010, House of Commons, London.

Da Pieve, Chiara and Missailidis, Sotiris (2010). Development of anti MUC-1 DNA aptamers for the imaging of breast cancer. In: SET for Britain 2010, 8 Mar 2010, House of Commons, London.

Pinto, Nelson S.; Monteiro, Milena B.; Santos-Filho, Sebastião D.; Paiva, Dulciane; Tavares, A.; Missailidis, Sotiris; Marin, Pedro J. and Bernardo-Filho, Mario (2010). Postmenopausal/menopause, bone mineral density and whole body vibration: a short review. Journal of Medicine and Medical Sciences, 1(11) pp. 516–525.

Missailidis, Sotiris and Hardy, Alison (2009). Aptamers as inhibitors of target proteins. Expert opinion in therapeutic patents, 19(8) pp. 1073–1082.

Arnold, Steve and Missailidis, Sotiris (2009). Development of aptamers that bind to BACE1. Alzheimer's & Dementia, 5(4 Sup.) P416-P416.

Hyde, C.A.C. and Missailidis, S. (2009). Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis. International Immunopharmacology, 9(6) pp. 701–715.

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Ragazzon, Patricia A.; Bradshaw, Tracey; Matthews, Charlie; Iley, Jim and Missailidis, Sotiris (2009). The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Research, 29 pp. 2273–2283.

Ragazzon, Patricia A.; Iley, Jim and Missailidis, Sotiris (2009). Structure-activity studies of the binding of the flavonoid scaffold to DNA. Anticancer Research, 29(6) pp. 2285–2293.

Ferreira, Cátia S. M.; Cheung, Melissa C.; Missailidis, Sotiris; Bisland, Stuart and Gariépy, Jean (2009). Phototoxic aptamers selectively enter and kill epithelial cancer cells. Nucleic Acids Research, 37(3) pp. 866–876.

Velasco-Garcia, Maria and Missailidis, Sotiris (2009). New trends in aptamer-based electrochemical biosensors. Gene Therapy and Molecular Biology, 13(1) pp. 1–10.

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Da Pieve, Chiara; Perkins, Alan C. and Missailidis, Sotiris (2009). Anti-MUC1 aptamers: radiolabelling with ^99mTc and biodistribution in MCF-7 tumour-bearing mice. Nuclear Medicine and Biology, 36(6) pp. 703–710.

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Smith, Gary Robert and Missailidis, Sotiris (2009). Learning from cancer: the adaptive growth, wound and immune responses. Gene Therapy and Molecular Biology, 13(A) pp. 158–185.

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Bernardo-Filho, Mario; Missailidis, Sotiris; Santos-Filho, Sebastião and Fonseca, Adenilson (2009). Prostate cancer therapies, complications and sixteen questions that the patients and the multidisciplinary team are interested in. Gene Therapy and Molecular Biology, 13(B) pp. 254–263.

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Missailidis, Sotiris (2009). Design and use of aptamers as novel inhibitors, therapeutic and imaging agents in cancer and inflammatory disease. In: XXIV Annual Reunion of the Federation of the Societies of Experimental Biology of Brazil (FeSBE), 19-22 Aug 2009, Agua de Lindoia, Brazil.

Simmons, Suzanne; Brenchley, P. E. C.; Iley, James; McKenzie, E. A.; Velasco, Maria and Missailidis, Sotiris (2009). Anti-heparanase aptamers as inhibitors of angiogenesis and tissue remodelling. In: YSL Networking Angiogenesis Conference, 14 Jul 2009.

Missailidis, Sotiris; Perkins, Alan; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson and Bernardo-Filho, Mario (2008). Aptamer-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of epithelial tumors. Brazilian Archives of Biology and Technology, 51 pp. 77–82.

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Bernardo-Filho, Mario; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson; Carter, Kevin and Missailidis, Sotiris (2008). Nuclear medicine procedures and the evaluation of male sexual organs: a short review. Brazilian Archives of Biology and Technology, 51 pp. 13–21.

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Diniz, Claudia Leite; Santos Do Carmo, Fernanda; Santos de Almeida, Danielle; Missailidis, Sotiris; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson and Bernardo-Filho, Mario (2008). Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents. Brazilian Archives of Biology and Technology, 51 pp. 215–219.

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Missailidis, Sotiris (2008). Combinatorial approaches to anticancer drug design. In: Missailidis, Sotiris ed. Anticancer Therapeutics. Chichester, UK: Wiley, pp. 17–28.

Simmons, S. C.; Velasco, M. N.; Brenchley, P. E. C.; McKenzie, E. and Missailidis, S. (2008). Developing aptamers as effective anticancer agents or recognition units in biosensor technologies. Anticancer Research, 28(5C) p. 3486.

Da Pieve, C.; Iley, J. N.; Perkins, A. and Missailidis, S. (2008). Development of anti-MUC1 DNA aptamers for the imaging of breast cancer. In: EACR20, 5-8 Jul 2008, Lyon, France.

Ferreira, C. S. M.; Papamichael, K.; Guilbault, G.; Schwarzacher, T.; Gariepy, J. and Missailidis, S. (2008). DNA aptamers against the MUC1 tumour marker: design of aptamer–antibody sandwich ELISA for the early diagnosis of epithelial tumours. Analytical and Bioanalytical Chemistry, 390(4) pp. 1039–1050.

Cheng, Mai-Kim; Modi, Chetna; Cookson, Jennifer C.; Hutchinson, Ian; Heald, Robert A.; McCarroll, Andrew J.; Missailidis, Sotiris; Tanious, Farial; Wilson, W. David; Mergny, Jean-Louis; Laughton, Charles A. and Stevens, Malcolm F. G. (2008). Antitumor Polycyclic Acridines. 20. Search for DNA Quadruplex Binding Selectivity in a Series of 8,13-Dimethylquino[4,3,2-kl]acridinium Salts: Telomere-Targeted Agents. Journal of Medicinal Chemistry, 51(4) pp. 963–975.

Khan, Huma and Missailidis, Sotiris (2008). Aptamers in oncology: a diagnostic perspective. Gene Therapy and Molecular Biology, 12(A) pp. 111–128.

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Missailidis, Sotiris ed. (2008). Anticancer Therapeutics. Chichester: Wiley.

Missailidis, Sotiris (2008). Future trends in cancer therapeutics. In: Missailidis, Sotiris ed. Anticancer Therapeutics. Chichester, UK: Wiley, pp. 387–392.

Makwana, Vaidehi; Simmons, Suzanne and Missailidis, Sotiris (2008). Aptamers as anticancer agents. In: Missailidis, Sotiris ed. Anticancer Therapeutics. Chichester, UK: Wiley, pp. 331–346.

Khan, Huma and Missailidis, Sotiris (2008). Antisense agents. In: Missailidis, Sotiris ed. Anticancer Therapeutics. Chichester, UK: Wiley, pp. 317–330.

Makwana, Vaidehi; Khan, Huma; Courtenay-Luck, Nigel and Missailidis, Sotiris (2008). Functionalisation of aptamers for the development of effective cancer therapeutics. Anticancer Research, 28(5C) pp. 3394–3395.

Da Pieve, Chiara; Perkins, Alan and Missailidis, Sotiris (2008). Development of aptamers as targeted radiopharmaceuticals for the diagnostic imaging and radiotherapy of breast cancer. In: 8th International Conference of Anticancer Research, 17-22 Oct 2008, Kos, Greece.

Khan, Huma; Makwana, Vaidehi; Courtenay-Luck, Nigel and Missailidis, Sotiris (2008). Development and characterisation of aptamers as inhibitors of vital pathways in cancer therapy. Anticancer Research, 28(5C) pp. 3346–3347.

Missailidis, Sotiris (2008). Therapeutic and diagnostic applications of aptamers in cancer. Anticancer Research, 28(5C) pp. 3408–3409.

Agostinho, Raquel Terra; David Santos-Filho, Sebastião; De Souza da Fonseca, Adenilson; Missailidis, Sotiris and Bernardo-Filho, Maria (2008). The effect of an extract from Ganoderma lucidum (reishi) on the labeling of blood constituents with technetium-99m and on the survival of Escherichia coli. Brazilian Archives of Biology and Technology, 51 pp. 157–163.

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David Santos-Filho, S; De Souza da Fonseca, A; Emmanuel, A; Missailidis, Sotiris and Bernardo-Filho, M (2008). Prostate cancer, treatment modalities and complications: an evaluation of the scientific literature. Brazilian Archives of Biology and Technology, 51 pp. 51–57.

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David Santos-Filho, S; Missailidis, Sotiris; De Souza da Fonseca, A and Bernardo-Filho, M (2008). Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature. Brazilian Archives of Biology and Technology, 51 pp. 45–51.

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Khan, H.; Makwana, V.; Courtenay-Luck, N. and Missailidis, S. (2008). Development and characterisation of aptamers for cancer therapy. European Journal of Cancer Supplements, 6(9) pp. 137–138.

Perkins, Alan and Missailidis, Sotiris (2007). Radiolabelled aptamers for tumour imaging and therapy. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 51(4) pp. 292–296.

Ferreira, C. S. M.; Gariepy, J. and Missailidis, S. (2007). Aptamers directed to MUC1. univ open [gb]; univ toronto [ca]; gariepy jean [ca]; ferreira catia sofia matos [ca]; missailidis sotiris [gb], WO2007129114.

Missailidis, Sotiris ed. (2007). The Cancer Clock. Chicester, UK: John Wiley & Sons.

Missailidis, Sotiris (2007). Genetics and cancer. In: Missailidis, Sotiris ed. The Cancer Clock. Chicester, UK: John Wiley & Sons, pp. 57–75.

Ferreira, Catia S. M. and Missailidis, Sotiris (2007). Aptamer-based therapeutics and their potential in radiopharmaceutical design. Brazilian Archives of Biology and Technology, 50 pp. 63–76.

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Missailidis, Sotiris and Perkins, Alan (2007). Aptamers as Novel Radiopharmaceuticals: Their Applications and Future Prospects in Diagnosis and Therapy. Cancer Biotherapy and Radiopharmaceuticals, 22(4) pp. 453–468.

Borbas, K. Eszter; Ferreira, Catia S. M.; Perkins, Alan; Bruce, James I. and Missailidis, Sotiris (2007). Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer. Bioconjugate Chemistry, 18(4) pp. 1205–1212.

Alcaro, Stefano; Artese, Anna; Iley, James N.; Maccari, Rosanna; Missailidis, Sotiris; Ortuso, Francesco; Ottana, Rosaria; Ragazzon, Patricia and Vigorita, Maria Gabriella (2007). Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold. Bioorganic and Medicinal Chemistry Letters, 17(9) pp. 2509–2514.

Strat, Daniela; Missailidis, Sotiris and Drake, Alex F. (2007). A Novel Methodological Approach for the Analysis of Host-Ligand Interactions. ChemPhysChem, 8(2) pp. 270–278.

Ferreira, C.S.M.; Matthews, C.S. and Missailidis, S. (2006). DNA Aptamers That Bind to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers. Tumor Biology, 27(6) pp. 289–301.

Da Pieve, C.; Iley, J. N.; Perkins, A. and Missailidis, S. (2006). Development of anti MUC1 DNA aptamers for the imaging and radiotherapy of breast cancer. Breast Cancer Research, 8 pp. 15–16.

Da Pieve, C.; Bactyari, A.; Perkins, A.; Missailidis, S. and Iley, J. (2006). Design of an anti MUC1 DNA aptamer as novel radiopharmaceutical for the diagnostic imaging and targeted radiotherapy of tumours. European Journal of Cancer Supplements, 4(12) pp. 65–66.

Da Pieve, C.; Bakhtyari, A.; Perkins, A. C.; Iley, J. and Missailidis, S. (2006). DNA aptamers as novel radiopharmaceuticals for imaging and targeted radiotherapy of epithelial tumours. In: European Association of Nuclear Medicine '06, 30 Sep - 04 Oct 2006, Athens, Greece.

Missailidis, Sotiris and Perkins, Alan (2005). DNA aptamers for in vivo molecular targeted imaging and therapy. Tumor Biology, 27(Suppl. 1,) p. 22.

Missailidis, Sotiris; Modi, Chetna; Trapani, Valentina; Laughton, Charles A. and Stevens, Malcolm F.G. (2005). Antitumor Polycyclic Acridines. Part 16. Triplex DNA as a Target for DNA-Binding Polycyclic Acridine Derivatives. Oncology Research incorporating Anticancer Drug Design, 15(2) pp. 95–105.

Perkins, Alan and Missailidis, Sotiris (2005). Radiolabelled aptamers for imaging and therapy. World Journal of Nuclear Medicine, 4(2) S55-S56.

Missailidis, Sotiris; Thomaidou, Despina; Borbas, K. Eszter and Price, Mike R. (2005). Selection of aptamers with high affinity and high specificity against C595, an anti-MUC1 IgG3 monoclonal antibody, for antibody targeting. Journal of Immunological Methods, 296(1-2) pp. 45–62.

Ragazzon, P.; Iley, J. N. and Missailidis, S. (2005). Novel DNA-binding chemotherapeutic agents based on flavonoid scaffolds. In: NCRI Cancer Conference, 2-5 Oct 2005, Birmingham, U.K..

Perkins, A. C. and Missailidis, S. (2005). Radiolabelled aptamers for imaging and therapy. In: International Conference on Radiopharmaceutical Therapy, 11-14 Oct 2005, Limasol, Cyprus.

Missailidis, S. and Perkins, A. C. (2005). DNA aptamers for in vivo molecular targeted imaging and therapy. In: ISOBM 2005, 24-28 Sep 2005, Rhodes, Greece.

Smith, Gary Robert and Missailidis, Sotiris (2004). Cancer, inflammation and the AT1 and AT2 receptors. Journal of Inflammation, 1(3)

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Ferreira, Catia and Missailidis, Sotiris (2004). DNA aptamers that recognize the MUC1 tumour marker. European Journal of Cancer Supplements, 2(8) p. 19.

Ferreira, C. and Missailidis, S. (2004). DNA aptamers that recognise the MUC1 tumour marker. European Journal of Cancer Supplements, 2(8) p. 19.

Ragazzon, Patricia; Iley, James and Missailidis, Sotiris (2004). Development of novel DNA-binding chemotherapeutic agents based on flavonoid scaffolds of active ingredients isolated from Chinese herbal remedies. In: CNIO Cancer Conference: Structural Biology of Cancer Targets, 19-22 Sep 2004, Madrid, Spain.

Ragazzon, P.; Iley, J. N. and Missailidis, S. (2004). Structure-activity related studies between the flavonoid skeleton and DNA duplex, triplex and tetraplex structures. In: Frontiers in Chemical Biology: The Chemical Biology of Cancer, 8-10 Sep 2004.

Missailidis, S. and Ferreira, C. S. M. (2004). DNA oligonucleotide aptamers as novel targeted therapeutic and imaging agents. In: 18th Meeting of the European Association for Cancer Research (EACR-18), 3-6 Jul 2004, Innsbruck, Austria.

Missailidis, Sotiris (2003). Targeting of Antibodies using Aptamers. In: Lo, Benny K.C. ed. Antibody engineering: methods and protocols. 2nd edition. Methods in Molecular Biology, 51. Humana Press, pp. 547–555.

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Missailidis, Sotiris and Brady, Kevin (2003). Characterization of antibody-antigen interactions by fluorescence spectroscopy. In: Lo, Benny and Chen, Yu Wai eds. Antibody engineering: methods and protocols. Methods in molecular biology (51). Totowa, NJ, USA: Humana Press, pp. 431–441.

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Bruce, James; Missailidis, Sotiris; Borbas, K. Eszter and Ferreira, Catia Sofia Matos (2003). Detection, Monitoring and Treatment of Cancer. The Open University, PCT/GB2004/001028.

Strat, D. and Missailidis, S. (2003). The study of the interaction between Formoterol derivatives and beta-cyclodextrin by means of CD spectroscopy. In: Physics Conference TIM-03, 28-29 Nov 2003, Timisoara, Romainia.

Missailidis, S. and Matthews, C. (2003). Patient specific therapies using aptamers: Selection of high affinity and specificity oligonucleotide ligands against human tumour cell lines. In: New Trends in Nucleic Acid Based Biosensors, 25-28 Oct 2003, Florence, Italy.

Ragazzon, P.; Iley, J. N. and Missailidis, S. (2003). Molecular encounters between active ingredients from herbal remedies and DNA. In: Fourth European Workshop in Drug Design (4EWDD), 25 May - 01 Jun 2003, Siena, Italy.

Ferreira, C. S. M. and Missailidis, Sotiris (2003). Anti-idiotypic aptamers: Targeting the idiotypic antibodies in the surface of B-cell lymphomas for early diagnosis and patient specific therapy. In: 2003 Cell Target Workshop, Mar 2003, Budapest, Hungary.

Missailidis, S.; Thomaidou, D. and Price, M. R. (2003). Development of High Affinity and High Specificity Oligonucleotide Ligands to the Clinically Relevant Anti-MUC1 Monoclonal Antibody C595. In: 2003 Cell Target Workshop, Mar 2003, Budapest, Hungary.

Borbas, K. E.; Ferreira, C. S. M.; Bruce, J. I. and Missailidis, S. (2003). Aptamers as new tools for disease diagnosis and therapy. In: 2003 Cell Target Workshop, Mar 2003, Budapest, Hungary.

Murray, A.; Missailidis, S. and Price, M.R. (2002). Epitope Affinity Chromatography and Biophysical Studies of Monoclonal Antibodies and Recombinant Antibody Fragments. Journal of Chromatographic Science, 40(6) pp. 343–349.

Smith, Richard G.; Missailidis, Sotiris and Price, Michael R. (2002). Purification of anti-MUC1 antibodies by peptide mimotope affinity chromatography using peptides derived from a polyvalent phage display library. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 766(1) pp. 13–26.

Missailidis, Sotiris; Stanslas, Johnson; Modi, Chetna; Ellis, Michael J.; Robins, R Adrian; Laughton, Charles A. and Stevens, Malcolm F.G. (2002). Antitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anti-cancer drug design. Oncology Research incorporating Anticancer Drug Design, 13(3) pp. 175–189.

Ferreira, C. S. M. and Missailidis, Sotiris (2002). Aptamers. Radiopharmaceuticals of the future. In: Advances in Nuclear Medicine and in Radiopharmaceuticals – ANMR 2002, 26-28 Sep 2002, Brazil.

Petra, M.; Theologis, T.; Missailidis, S.; Anastasopoulou, Y. and Theophanides, T. (2002). Study of the consistency and structure of child bone using micro-FTIR spectroscopy. In: Congress on the Study of Bone Metabolism, Apr 2002, Myconos, Greece.

Missailidis, Sotiris; Modi, C.; Laughton, C. and Stevens, M. F. G. (2001). Inhibiting Topoisomerases: The Chemical and Biological Activity of Novel Pentacyclic Acridinium Salts. In: IIAR conferences 2001, 30 May - 2 Jun 2001, Kapandriti, Athens, Greece.

Modi, C.; Missailidis, Sotiris; Laughton, C. and Stevens, M. F. G. (2001). Triplex DNA, a novel target for a structure selective DNA binding class of antitumour compounds. In: IIAR Conferences 2001: New Anticancer Agents, 9-12 Jun 2001, Kapandriti, Athens, Greece.