Currently browsing: Items authored or edited by Jane Loughlin https://orcid.org/0000-0003-4769-3740

Fatima, Nayab; Akcan, Ugur; Kaya, Mehmet; Gromnicova, Radka; Loughlin, Jane; Sharrack, Basil and Male, David (2021). Tissue distribution and cellular localization of gold nanocarriers with bound oligonucleotides. Nanomedicine, 16(9) pp. 709–720.

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Hague, J. P.; Mieczkowski, P. W.; O'Rourke, C.; Loughlin, A. J. and Phillips, J. B. (2020). Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces. Physical Review Research, 2(4), article no. 043217.

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Alimajstorovic, Zerin; Pascual-Baixauli, Ester; Hawkes, Cheryl A.; Sharrack, Basil; Loughlin, A. Jane; Romero, Ignacio A. and Preston, Jane E. (2020). Cerebrospinal fluid dynamics modulation by diet and cytokines in rats. Fluids and barriers of the CNS, 17, article no. 10 (2020).

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Fatima, Nayab; Gromnicova, Radka; Loughlin, Jane; Sharrack, Basil and Male, David (2020). Gold nanocarriers for transport of oligonucleotides across brain endothelial cells. PLOS ONE, 15(9), article no. e0236611.

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O’Rourke, Caitriona; Lee-Reeves, Charlotte; Drake, Rosemary AL; Cameron, Grant WW; Loughlin, A Jane and Phillips, James B (2017). Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration. Journal of Tissue Engineering, 8 pp. 1–9.

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O'Rourke, Caitriona; Drake, Rosemary A. L.; Cameron, Grant W. W.; Loughlin, A. Jane and Phillips, James B. (2015). Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue. Journal of Biomaterials Applications, 30(5) pp. 599–607.

Georgiou, Melanie; Golding, Jon P.; Loughlin, Alison J.; Kingham, Paul J. and Phillips, James B. (2015). Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials, 37 pp. 242–251.

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East, Emma; Johns, Noémie; Georgiou, Melanie; Golding, Jon P.; Loughlin, A. Jane; Kingham, Paul J. and Phillips, James B. (2013). A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury. Regenerative Medicine, 8(6) pp. 739–746.

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Georgiou, Melanie; Bunting, Stephen C. J.; Davies, Heather A.; Loughlin, Alison J.; Golding, Jonathan P. and Phillips, James B. (2013). Engineered neural tissue for peripheral nerve repair. Biomaterials, 34(30) pp. 7335–7343.

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Daya, Sandeep; Davies, Heather; Colyer, Frances; Tuffnell, Joshua; Loughlin, Jane and MacQueen, Hilary (2013). Fuelling an immune response: an ultrastructural study of immune-stimulated lymph nodes. Applied Cell Biology, 2(1)

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Tai, Leon M.; Reddy, P. Sreekanth; Lopez-Ramirez, M. Alejandro; Davies, Heather A.; Male, A. David K.; Loughlin, A. Jane and Romero, Ignacio A. (2009). Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Research, 1292 pp. 14–24.

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Tai, Leon M.; Loughlin, A. Jane; Male, David K. and Romero, Ignacio A. (2009). P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-β. Journal of Cerebral Blood Flow and Metabolism, 29(6) pp. 1079–1083.

Loughlin, Jane; East, Emma; Golding, Jon and Phillips, James (2009). Developing a 3D culture model of CNS myelination. Glia, 57(S13) S119.

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Maru, Seema V.; Holloway, Karen A.; Flynn, Geraldine; Lancashire, Christine L.; Loughlin, A. Jane; Male, David K. and Romero, Ignacio A. (2008). Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation. Journal of Neuroimmunology, 199(1-2) pp. 35–45.

Daya, Sandeep; Loughlin, Alison J. and MacQueen, Hilary A. (2007). Culture and differentiation of preadipocytes in two-dimensional and three-dimensional in vitro systems. Differentiation, 75(5) pp. 360–370.

Flynn, Geraldine; Maru, Seema; Loughlin, Jane; Romero, Ignacio A. and Male, David (2003). Regulation of chemokine receptor expression in human microglia and astrocytes. Journal of Neuroimmunology, 136(1-2) pp. 84–93.

Williams, Daniel D.; Price, Nigel T.; Loughlin, A. Jane and Proud, Christopher G. (2001). Characterization of the Mammalian Initiation Factor eIF2B Complex as a GDP Dissociation Stimulator Protein. Journal of Biological Chemistry, 276(27) pp. 24697–24703.

Paulin, Fiona E.M.; Campbell, Linda E.; O'Brien, Kirsty; Loughlin, Jane and Proud, Christopher G. (2001). Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein. Current Biology, 11(1) pp. 55–59.

Welsh, Gavin I.; Miller, Christa M.; Loughlin, Jane A.; Price, Nigel T. and Proud, Christopher G. (1998). Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Letters, 421(2) pp. 125–130.

Loughlin, A. J.; Copelman, C. A.; Hall, A.; Armer, T.; Young, B. C.; Landon, D. N. and Cuzner, M. L. (1997). Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages. Journal of neuroscience research, 47(4) pp. 384–392.

Cuzner, M. L.; Gveric, D.; Strand, C.; Loughlin, Jane; Paemen, L.; Opdenakker, G. and Newcombe, J. (1996). The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: comparison of stages in lesion evolution. Journal of Neuropathology and Experimental Neurology, 55(12) pp. 1194–1204.

Loughlin, A. J. and Woodroofe, M. N. (1996). Inhibitory effect of interferon-gamma on LPS-induced interleukin 1 beta production by isolated adult rat brain microglia. Neurochemistry International, 29(1) pp. 77–82.

Loughlin, A. J.; Woodroofe, M. N.; Cuzner, M. L.; Honegger, P.; Comte, V. and Matthieu, J. M. (1994). Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: effects of macrophage enrichment. Journal of neuroscience research, 37(5) pp. 647–653.

Cuzner, M. L.; Loughlin, A. J.; Mosley, K. and Woodroofe, M. N. (1994). The role of microglia macrophages in the processes of inflammatory demyelination and remyelination. Neuropathology and Applied Neurobiology, 20(2) pp. 200–201.

Loughlin, A. J.; Woodroofe, M. N. and Cuzner, M. L. (1993). Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids. Immunology, 79(1) pp. 125–130.

Loughlin, A. J.; Woodroofe, M. N. and Cuzner, M. L. (1992). Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation. Immunology, 75(1) pp. 170–175.

Woodroofe, M. N.; Sarna, G. S.; Wadhwa, M.; Hayes, G. M.; Loughlin, A. J.; Tinker, A. and Cuzner, M. L. (1991). Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. Journal of neuroimmunology, 33(3) pp. 227–236.

O'Rourke, Caitriona; Drake, Rosemary; Loughlin, Jane and Phillips, James (2014). Adapting aligned, stabilised 3D tissues for large-scale neurobiological research. In: Tissue and Cell Engineering Society Annual Conference 2014, 2-4 Jul 2014, Newcastle, p. 29.

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O'Rourke, Caitriona; Loughlin, Jane; Drake, Rosemary and Phillips, James (2014). Development of stabilised aligned CNS co-culture technology to model the behaviour of a range of neural cell types. In: 3D Cell Culture 2014, 25-27 Jun 2014, Freiburg Germany.

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Daya, Sandeep; Davies, Heather; Colyer, Frances; Tuffnell, Joshua; Loughlin, Jane and MacQueen, Hilary (2013). Adipocytes: a role in immunological memory? In: 40th UK Adipose Tissue Discussion Group and BHF Centre for Research Excellence Adipose Tissue Workshop, 12-13 Dec 2013, Edinburgh, UK.

O'Rourke, Caitriona; Drake, Rosemary; Loughlin, Jane and Phillips, James (2013). Adapting aligned stabilised hydrogels to facilitate large scale drug screening and neurobiological research. In: Future Investigators Of Regenerative Medicine Symposium, 30 Sep - 03 Oct 2013, Platja d'Aro, Spain.

Georgiou, Melanie; Golding, Jon; Loughlin, Jane and Phillips, James (2013). Fabrication of an endoneurium using engineered neural tissue within a peripheral nerve repair conduit. In: Tissue Engineering and Regenerative Medicine International Society - EU Meeting, 17-20 Jun 2013, Istanbul, Turkey.

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O'Rourke, Caitriona; Loughlin, A. J.; Drake, Rosemary and Phillips, J. B. (2013). A multi-well plate model of reactive gliosis for high throughput screening of potential CNS therapies. In: BNA Festival of Neuroscience, 07-10 Apr 2013, London.

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O'Rourke, C.; Loughlin, J.; Drake, R. and Phillips, J. B. (2012). Stabilisation of hydrogels containing neural cells to form CNS tissue models for monitoring neuronal and glial cell behaviour in vitro. In: Neuroscience 2012, 13-17 Oct 2012, New Orleans.

Georgiou, Melanie; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James (2012). A living replacement tissue for peripheral nerve that can enhance regeneration in vitro and in vivo. In: Tissue Engineering and Regenerative Medicine International Society - World Congress 2012, 5-8 Sep 2012, Vienna, Austria.

Georgiou, Melanie; Kingham, Paul; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James (2012). A nerve repair conduit containing differentiated adipose-derived stem cells within engineered neural tissue can support and guide neuronal growth in vitro and in vivo. In: Tissue Engineering and Regenerative Medicine International Society - World Congress 2012, 5-8 Sep 2012, Vienna, Austria.

O'Rourke, Caitriona; Loughlin, Jane; Drake, Rosemary and Phillips, James (2012). Optimising glial cell alignment in 3D culture to facilitate the development of neural tissue models for CNS research. In: Tissue Engineering and Regenerative Medicine International Society - World Congress 2012, 5-8 Sep 2012, Austria, Vienna.

Osei, E. T.; Evans, L.; Phillips, J. B. and Loughlin, A. J. (2012). Developing a 3D co-culture model to simulate perinatal hypoxic-ischaemic brain injury in preterm infants. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 Jul 2012, Liverpool, UK.

Johns, N.; East, E.; Golding, J. P.; Loughlin, A. J. and Phillips, J. B. (2012). Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 Jul 2012, Liverpool, UK.

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O'Rourke, C. M.; Loughlin, A. J.; Drake, R. and Phillips, J. B. (2012). Defining glial cell self-alignment parameters for 3D CNS tissue models. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 Jul 2012, Liverpool, UK.

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Georgiou, M.; Loughlin, J.; Golding, J. P.; Kingham, P. J. and Phillips, J. B. (2012). Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cells. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 Jul 2012, Liverpool, UK.

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Georgiou, Melanie; Kingham, Paul; Golding, Jon; Loughlin, Jane and Phillips, James (2012). Engineered neural tissue with columns of aligned Schwann cell-like cells from differentiated adipose-derived stem cells can support and guide neuronal growth in vitro. In: 3rd International Conference on Stem Cell Engineering "Designing Cellular Therapies", 29 Apr - 02 May 2012, Seattle, US.

Phillips, J. and Loughlin, J. (2011). Monitoring glial cell behaviour and neuron-glial interactions in 3D hydrogel and aggregate culture systems. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 Sep 2011, Prague, Czech Republic.

Georgiou, M.; East, E.; Loughlin, J.; Golding, J. and Phillips, J. (2011). Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 Sep 2011, Prague, Czech Republic.

Georgiou, Melanie; Loughlin, Jane; Golding, Jon and Phillips, James (2011). Aligned cellular and acellular collagen guidance substrates for peripheral nerve repair. In: Tissue and Cell Engineering Society, 19-21 Jul 2011, Leeds.

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Georgiou, M.; East, E.; Loughlin, A. J.; Golding, J. P. and Phillips, J. B. (2011). A tissue engineered collagen conduit containing columns of aligned Schwann cells supports neuronal regeneration in vitro. In: 2011 PNS Biennial Meeting of the Peripheral Nerve Society, 25-29 Jun 2011, Potomac, Maryland, US.

Georgiou, M.; East, E.; Loughlin, J.; Golding, J.P. and Phillips, J.B. (2010). Schwann cells in collagen gels survive plastic compression and maintain their alignment: development of a cellular biomaterial for peripheral nerve repair. In: Tissue and Cell Engineering Society, 28-30 Jul, Manchester, U.K..

East, E.; Georgiou, M.; Loughlin, A.J.; Golding, J.P. and Phillips, J.B. (2010). Plastic compression of aligned cellular collagen gels for nervous system repair. In: Tissue Engineering and Regenerative Medicine International Society - EU Meeting, 13-17 Jun, Galway, Ireland.

Daya, Sandeep; Loughlin, Jane and MacQueen, Hilary (2009). Three-dimensional adipocyte cultures and co-cultures to study tissue interactions. In: NC3Rs/BBSRC Symposium Tissue Engineering: a new dimension to animal replacement, 2-3 Apr 2009, Royal College of Surgeons, London UK.

Daya, S.; Loughlin, J. and MacQueen, H. (2006). Development of a 3D coculture system to study adipocyte and lymph node cell interactions. In: Tissue and cell engineering systems meeting 2006, 3-4 Jul 2006, Sheffield, UK.

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Daya, Sandeep; Loughlin, Jane and MacQueen, Hilary (2005). Development of a three-dimensional co-culture system to study adipocyte and lymph node cell interactions. In: British Society for Immunology Winter meeting 2005, 6-9 Dec 2005, Harrogate, UK.

MacQueen, Hilary; Loughlin, Jane and Daya, Sandeep (2007). Three-dimensional cell culture. The Open University, PCT/GB2007/050161.